Dimethylamine → HCID 18706951, compound

Participants

Reaction Steps

5-Acetoxymethyl-3-(4-benzyloxyphenyl)pyrrolo[2,1,5-cd]indolizine-1,2-dicarboxylic acid anhydride was reacted with dimethylamine by the general synthetic principles outlined in example 62, step 9, to afford 5-acetoxymethyl-3-(4-benzyloxyphenyl)-2-dimethylcarbamoylpyrrolo[2,1,5-cd]indolizine-1-carboxylic acid as crystals in 68% yield. 1H-NMR (DMSO-d6, 300 MHz) δ: 2.22 (s, 3H); 2.72 (s, 3H); 3.08 (s, 3H); 5.20 (s, 2H); 5.70 (s, 2H); 7.19 (d, 2H); 7.32-7.53 (m, 5H); 7.82 (d, 2H); 7.89 (s, 1H); 8.02 (d, 1H); 8.32 (d, 1H); 12.78 (br s, 1H).

Provenance & Evidence