Butyn-2-one → HCID 53780209, compound

Participants

Reaction Steps

2-(4-(tert-Butyldimethylsilanyloxymethyl)phenyl)-1-ethylindolizine was reacted with 3-butyn-2-one by the general synthetic principles outlined in example 73, step 1, to afford 4-acetyl-2-(4-(tert-butyldimethylsilanyloxymethyl)phenyl)-1-ethylpyrrolo[2,1,5-cd]indolizine in 45% yield. 1H-NMR (CDCl3, 200 MHz) δ: 0.17 (s, 6H); 0.99 (s, 9H); 1.47 (t, 3H); 2.72 (s, 3H); 3.22 (q, 2H); 4.86 (s, 2H); 7.51 (d, 2H); 7.74 (d, 2H); 7.80-7.96 (m, 3H); 8.48 (dd, 1H).

Provenance & Evidence