HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trimethylsilyl cyanide → 5-Isopropyl-pyridine-2-sulphonic acid 2-(2-cyano-pyridin-4-yl)-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trimethylsilyl cyanide | HCID 82115 | — |
| Edukt | N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-morpholinopyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide | HCID 22377859 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 5-Isopropyl-pyridine-2-sulphonic acid 2-(2-cyano-pyridin-4-yl)-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl-amide | HCID 17891134 | — |
Reaktionsschritte
reacting the product of step e) with trimethylsilylcyanide and triethylamine to form 5-isopropyl-pyridine-2-sulphonic acid 2-(2-cyano-pyridin-4-yl)-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl-amide, and
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06080866 |
| Quelldatensatz | uspto-grants-2000_06 |
| ORD ID | ord-46092d4a94b248b2baf65ff6d3c8eda8 |
| Quellennotiz | uspto-grants-2000_06 |