Ammonium Chloride → HCID 178489612, compound

HRID 1422206Notes

Reaction equation

[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH:13][C:14]2[N:19]=[C:18](N3CCOCC3)[N:17]=[C:16]([O:26][CH2:27][CH2:28][O:29]C(=O)NC3C=CC=CN=3)[C:15]=2[O:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=2[O:46][CH3:47])(=[O:12])=[O:11])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[Cl-].[NH4+:49].[N-:50]=[N+:51]=[N-:52].[Na+]>>[OH:29][CH2:28][CH2:27][O:26][C:16]1[N:17]=[C:18]([C:4]2[CH:1]=[CH:2][N:49]=[C:6]([C:7]3[NH:8][N:52]=[N:51][N:50]=3)[CH:5]=2)[N:19]=[C:14]([NH:13][S:10]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][N:8]=2)(=[O:12])=[O:11])[C:15]=1[O:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1[O:46][CH3:47]

Participants

Reactant 3

HCID 25517Ammonium Chloride

HCID 33557Sodium Azide

HCID 9809919Pyridin-2-yl-carbamic acid 2-[6-(5-isopropyl-pyridine-2-sulfonylamino)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yloxy]-ethyl ester

Product 1

HCID 178489612HCID 178489612, compound

Procedure

reacting the product of step f) with ammonium chloride and sodium azide to form 5-isopropyl-pyridine-2-sulfonic acid {6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-[2-(1H-tetrazol-5-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide.

Sources & evidence

ORD record: ord-018dd30a1cf84e4a9041530c04fd3407
Source dataset: uspto-grants-2000_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06080866

Reaction notes

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