HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 57141296, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | (r)-(4-benzylmorpholin-3-yl)methanol | HCID 1514271 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57141296 | HCID 57141296 | 95.2% |
Reaction Steps
(3R)-4-Benzylmorpholine-3-methanol (1.04 g, 5.0 mmol), t-butyldimethylchlorosilane (0.83 g, 5.5 mol), and imidazole (0.41 g, 6.0 mmol) were allowed to react in 5 mL of dichloromethane at room temperature overnight. The reaction product was purified by silica gel column chromatography (hexane:ethyl acetate=5:1) to obtain (3S)-3-(t-butyldimethylsilyloxy)methyl-4-benzylmorpholine (1.53 g, 95%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06080859 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-bc175e43311d43e281344511c0570f46 |
| Source note | uspto-grants-2000_06 |