Sodium Carbonate → Benzeneacetic acid, alpha-amino-2-chloro-, methyl ester, hydrochloride (1:1), (alphaS)-

HRID 1422295Notes

Reaction equation

HRID 1422295 reaction equation
[N+](C1C=C([N+]([O-])=O)C=CC=1C(N(C1C=CC=CC=1)CC(O)=O)=O)([O-])=O.[NH2:26][C@@H:27]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[Cl:38])[C:28]([O:30][CH3:31])=[O:29].C(=O)([O-])[O-].[Na+].[Na+]>>[ClH:38].[NH2:26][C@@H:27]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[Cl:38])[C:28]([O:30][CH3:31])=[O:29]

Participants

3

Reactant 2

HCID 10340Sodium CarbonateHCID 86755485methyl (+)-(S)-alpha-amino-alpha-(2-chlorophenyl)acetate (-)-(2,4-dinitrobenzoyl)phenylglycinate

Product 1

HCID 24887640Benzeneacetic acid, alpha-amino-2-chloro-, methyl ester, hydrochloride (1:1), (alphaS)-

Procedure

3 g of methyl (+)-(S)-α-amino-α-(2-chlorophenyl)acetate (-)-(2,4-dinitrobenzoyl)phenylglycinate are introduced into 20 ml of a 1 M solution of sodium carbonate and the mixture is extracted twice with 10 ml of ethyl acetate.

Workup

  1. extractionthe mixture is extracted twice with 10 ml of ethyl acetate

Sources & evidence

ORD record
ord-b7f10dfefede48cebfaddf0579ddc577
Source dataset
uspto-grants-2000_06
Patent number
US06080875

Reaction notes

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