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HRID1422297

反应详情

EQUATION

反应方程式

HRID 1422297 的结构方程式

REACTANTS

反应物

4
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：O=C(O)[C@H]1O[C@@H]1C(=O)O
HCID6454714

未命名化合物

结构：O=C(O)[C@H](Br)Cc1ccccc1
HCID11746403

(R)-2-BROMO-3-PHENYLPROPIONIC ACID

C9H9BrO2

结构：CC(O)=S.O=C([O-])[O-].[K+].[K+]
HCID178477231

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)S[C@@H](Cc1ccccc1)C(=O)O
HCID10176891

(2S)-2-(Acetylsulfanyl)-3-phenylpropanoic acid

C11H12O3S

收率 75%

PROCEDURE

实验过程

In the just cited patent application EP-0 524 553 (R)-2-bromo-3-phenyl-propionic acid is reacted, under nitrogen, with thioacetic acid/potassium carbonate in the presence of 1M sodium hydroxide to give (S)-2-acetylthio-3-phenyl-propionic acid which is extracted in ethyl acetate with a yield of 75%.