Diethyl Ether → HCID 11596091, compound

Participants

Reaction Steps

A solution of the product from step c (16.1 g, 42.4 mmol) in ethanol (300 ml) was cooled under an atmosphere of argon to 0° C. Sodium borohydride (1.57 g, 42.4 mmol) was added, the mixture stirred for 4 h and carefully quenched with saturated ammonium chloride. The mixture was extracted with dichloromethane (3×100 ml). The combined extracts were dried over magnesium sulfate, filtered and evaporated to give a white solid, which was dissolved in a 5% methanol/dichloromethane and preciptated with diethyl ether. Thus, the product was isolated as a colourless crystalline solid (9.34 g, 58%).

Provenance & Evidence