HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → Salicylaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Tin tetrachloride | HCID 24287 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Product | Salicylaldehyde | HCID 6998 | — |
Reaction Steps
The reaction in the step (I) is carried out by reacting a phenol derivative, a base and paraformaldehyde in the presence of SnCl2 and/or SnCl4 in an organic solvent at 0-85° C. to the conversion of 30-80%, preferably 50-80% and then to complete the reaction at 95-105° C. to give a salicylaldehyde derivative of the formula (3) in a high yield and in a high selectivity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06080895 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-62fb206bc44b411c94f4db2b7d57655b |
| Source note | uspto-grants-2000_06 |