HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422356Generated: October 31, 2026
Thionyl Chloride → 4-((5-(Chloromethyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride
https://huagongshe.com/reaction/1422356
Participants
| Role | Name | HCID | Charge |
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| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole | HCID 10198247 | — |
| Product | 4-((5-(Chloromethyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride | HCID 9795357 | — |
Reaction Steps
A suspension of 1-(4-cyanobenzyl)-5-hydroxymethylimidazole (Example 26, step D; 3.1 g, 14.5 mmol) in thionyl chloride (20 mL) was heated at 60° C. for 18 h. The excess thionyl chloride was removed in vacuo and the residue was azeotroped with CHCl3 (3×) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06080870 |
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| Source dataset | uspto-grants-2000_06 |
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| ORD ID | ord-e7fb3e7c1d11470aa974f46bf4f7d735 |
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| Source note | uspto-grants-2000_06 |
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