Sodium Hydroxide → HCID 18779184, compound

Participants

Reaction Steps

To a solution of the oxime from step B (0.51 g, 2.1 mmol) in THF (15 mL) at 0° C. was added BH3.THF (1M in hexane; 8 mL, 8 mmol) and the resulting solution was stirred at room temperature for 16 h then heated to reflux for 24 h. The solution was cooled to 0° C. and 1N NaOH (10 mL) was added slowly. After 1 h, the mixture was diluted with water, extracted with EtOAc (3×), washed with brine, dried and evaporated to give the title compound as an oil. This was used as such in the next step.

Provenance & Evidence