HCID 54025786, compound → HCID 54305770, compound

Participants

Reaction Steps

To 500 mL Parr flask was added (N-tert-butyl)-3-(1-hydroxybutyl)-4-biphenylcarboxamide (3.50 g, 10.75 mmol), abs EtOH (125 mL) and 10% palladium on carbon (3.50 g). This mixture was hyrogenolyzed at 60 psig and ambient temperature for 48 h. The catalyst was removed by filtration on a celite pad and the solvent was removed in vacuo. This material was chromatographed on silica gel using 10% EtOAc in hexane as eluant to afford the title compound as a white crystalline solid.

Provenance & Evidence