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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422367Generated: October 29, 2026

(1-Chloroethyl)benzene → 4-[(E,3S)-3-phenylbut-1-enyl]benzonitrile

https://huagongshe.com/reaction/1422367

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1-Chloroethyl)benzeneHCID 12648—
Reactant4-(2-Bromoethenyl)benzonitrileHCID 11745834—
ReagentSodium IodideHCID 5238—
Catalyst(3aR,3a'R,8aS,8a'S)-2,2'-(Cyclopropane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)HCID 11245230—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventDimethylacetamideHCID 31374—
Product4-[(E,3S)-3-phenylbut-1-enyl]benzonitrileHCID 10214180472%

Reaction Conditions

Temperature0 °C

Provenance & Evidence

DOI10.1021/acscatal.9b01785
Source datasetElectroreductive Coupling of Alkenyl and Benzyl Halides
ORD IDord-d31a21739b314cc7afcc8d2349e75056
Source noteElectroreductive Coupling of Alkenyl and Benzyl Halides