Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422368Generated: November 1, 2026

(1-Chloroethyl)benzene → 2-methoxy-5-[(E,3S)-3-phenylbut-1-enyl]pyridine

https://huagongshe.com/reaction/1422368

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1-Chloroethyl)benzeneHCID 12648—
Reactant5-(2-Bromoethenyl)-2-methoxypyridineHCID 154710494—
ReagentSodium IodideHCID 5238—
Catalyst(3aR,3a'R,8aS,8a'S)-2,2'-(Cyclopropane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)HCID 11245230—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventDimethylacetamideHCID 31374—
Product2-methoxy-5-[(E,3S)-3-phenylbut-1-enyl]pyridineHCID 13485067778%

Reaction Conditions

Temperature0 °C

Provenance & Evidence

DOI10.1021/acscatal.9b01785
Source datasetElectroreductive Coupling of Alkenyl and Benzyl Halides
ORD IDord-8261e6378225435c97217152a6c5ff85
Source noteElectroreductive Coupling of Alkenyl and Benzyl Halides