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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422378Generated: October 31, 2026

1-[(1R)-1-chloroethyl]-4-fluorobenzene → 1-fluoro-4-[(E,2S)-4-(4-methoxyphenyl)but-3-en-2-yl]benzene

https://huagongshe.com/reaction/1422378

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(1R)-1-chloroethyl]-4-fluorobenzeneHCID 2465967—
Reactant(E)-1-(2-Bromovinyl)-4-methoxybenzeneHCID 5355683—
ReagentSodium IodideHCID 5238—
Catalyst(3aR,3a'R,8aS,8a'S)-2,2'-(Cyclopropane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)HCID 11245230—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventDimethylacetamideHCID 31374—
Product1-fluoro-4-[(E,2S)-4-(4-methoxyphenyl)but-3-en-2-yl]benzeneHCID 16643904481%

Reaction Conditions

Temperature0 °C

Provenance & Evidence

DOI10.1021/acscatal.9b01785
Source datasetElectroreductive Coupling of Alkenyl and Benzyl Halides
ORD IDord-81ca5303d7f14f0884fca3ce0db15f66
Source noteElectroreductive Coupling of Alkenyl and Benzyl Halides