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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422380Generated: November 1, 2026

(E)-1-(2-Bromovinyl)-4-methoxybenzene → (3S)-1-(4-Methoxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-1-butene

https://huagongshe.com/reaction/1422380

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-1-(2-Bromovinyl)-4-methoxybenzeneHCID 5355683—
Reactant1-[(1R)-1-chloroethyl]-4-(trifluoromethoxy)benzeneHCID 28898675—
ReagentSodium IodideHCID 5238—
Catalyst(3aR,3a'R,8aS,8a'S)-2,2'-(Cyclopropane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)HCID 11245230—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventDimethylacetamideHCID 31374—
Product(3S)-1-(4-Methoxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-1-buteneHCID 10189963179%

Reaction Conditions

Temperature0 °C

Provenance & Evidence

DOI10.1021/acscatal.9b01785
Source datasetElectroreductive Coupling of Alkenyl and Benzyl Halides
ORD IDord-48cb5430272f43a2b77d809fadf5f623
Source noteElectroreductive Coupling of Alkenyl and Benzyl Halides