Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422381Generated: October 31, 2026

(E)-1-(2-Bromovinyl)-4-methoxybenzene → 1-methoxy-4-[(E,3S)-3-[4-(trifluoromethyl)phenyl]but-1-enyl]benzene

https://huagongshe.com/reaction/1422381

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-1-(2-Bromovinyl)-4-methoxybenzeneHCID 5355683—
Reactant1-[(1R)-1-chloroethyl]-4-(trifluoromethyl)benzeneHCID 52430517—
ReagentSodium IodideHCID 5238—
Catalyst(3aR,3a'R,8aS,8a'S)-2,2'-(Cyclopropane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)HCID 11245230—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventDimethylacetamideHCID 31374—
Product1-methoxy-4-[(E,3S)-3-[4-(trifluoromethyl)phenyl]but-1-enyl]benzeneHCID 16240240455%

Reaction Conditions

Temperature0 °C

Provenance & Evidence

DOI10.1021/acscatal.9b01785
Source datasetElectroreductive Coupling of Alkenyl and Benzyl Halides
ORD IDord-a405dd8472064079a9c5d05c0b13dd12
Source noteElectroreductive Coupling of Alkenyl and Benzyl Halides