HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422480Generated: October 30, 2026
2-Methylimidazole → 4-(2-(9-Isopropyl-2-(2-methyl-1H-imidazol-1-yl)-9H-purin-6-ylamino)ethyl)phenol
https://huagongshe.com/reaction/1422480
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Reactant | 4-(2-((2-Chloro-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol | HCID 75529970 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(2-(9-Isopropyl-2-(2-methyl-1H-imidazol-1-yl)-9H-purin-6-ylamino)ethyl)phenol | HCID 46215536 | — |
Reaction Steps
A microwave reaction tube was charged with 4-(2-(2-chloro-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol (30 mg, 0.091 mmol), 2-methyl-1H-imidazole (59 mg, 0.73 mmol) and 0.5 ml of NMP. The sealed tube was heated under microwave irradiation at 240° C. for 2 hr. The reaction mixture was purified by reverse-phase HPLC(C18 column, eluting with ACN—H2O 0.05% TFA) to afford the title compound as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08927281B2 |
|---|
| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-d813222626f94192ae75507c6b0c496d |
|---|
| Source note | uspto-grants-2015_01 |
|---|
