HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloropyridine-3-boronic acid → 4-(2-(2-(5-chloropyridin-3-yl)-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloropyridine-3-boronic acid | HCID 20111877 | — |
| Reactant | 4-(2-(2-iodo-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol | HCID 86643460 | — |
| Product | 4-(2-(2-(5-chloropyridin-3-yl)-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol | HCID 59408902 | — |
Reaction Steps
Following the procedure of Example 15d, 4-(2-(2-iodo-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol (b) was reacted with 5-chloropyridin-3-ylboronic acid. The crude product was purified by reverse-phase HPLC(C18 column, eluting with ACN—H2O 0.05% TFA) to afford the title compound as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927281B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-045430049ca74ad394c835b626cf5ffc |
| Source note | uspto-grants-2015_01 |