Tyramine → HCID 86643462, compound

HRID 1422486Notes

Reaction equation

HRID 1422486 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][N:8]([CH:11]([CH3:13])[CH3:12])[C:6]=2[N:7]=1.[NH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[N:3]=[C:4]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)[C:5]2[CH:10]=[CH:9][N:8]([CH:11]([CH3:13])[CH3:12])[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 5610TyramineHCID 72208044HCID 72208044, compound

Product 1

HCID 86643462HCID 86643462, compound

Procedure

Following the procedure of Example 128b, 2,4-dichloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (b) (0.278 g, 1.21 mmol) was reacted with tyramine. The crude residue was purified by silica gel chromatography (25 to 75% ethyl acetate in hexane eluant) to afford the title compound as a solid. MS m/z 331.1 (M+1).

Workup

  1. customThe crude residue was purified by silica gel chromatography (25 to 75% ethyl acetate in hexane eluant)

Sources & evidence

ORD record
ord-b21fa29ed1f94b8dbfde6b7cc4b8475b
Source dataset
uspto-grants-2015_01
Patent number
US08927281B2

Reaction notes

Loading…