(5-Fluoropyridin-3-yl)boronic acid → HCID 46214372, compound

HRID 1422487Notes

Reaction equation

HRID 1422487 reaction equation
Cl[C:2]1[N:3]=[C:4]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[C:5]2[CH:10]=[CH:9][N:8]([CH:11]([CH3:13])[CH3:12])[C:6]=2[N:7]=1.[F:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[N:29][CH:30]=1>>[F:24][C:25]1[CH:26]=[C:27]([C:2]2[N:3]=[C:4]([NH:14][CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[C:5]3[CH:10]=[CH:9][N:8]([CH:11]([CH3:13])[CH3:12])[C:6]=3[N:7]=2)[CH:28]=[N:29][CH:30]=1

Participants

3

Reactant 2

HCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 86643462HCID 86643462, compound

Product 1

HCID 46214372HCID 46214372, compound

Procedure

Following the procedure of Example 15d, 4-(2-(2-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl)phenol (20 mg, 0.06 mmol) was reacted with 5-fluoropyridin-3-ylboronic acid. The crude residue was purified by reverse-phase HPLC (C18 column, eluting with ACN—H2O 0.05% TFA) to afford the title compound as an off-white solid.

Workup

  1. customThe crude residue was purified by reverse-phase HPLC (C18 column, eluting with ACN—H2O 0.05% TFA)

Sources & evidence

ORD record
ord-f7280a22112e4c7b91fe37349fef95b4
Source dataset
uspto-grants-2015_01
Patent number
US08927281B2

Reaction notes

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