Tyramine → HCID 86643463, compound

HRID 1422488Notes

Reaction equation

HRID 1422488 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[NH2:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[N:3]=1

Participants

3

Reactant 2

HCID 5610TyramineHCID 86643464HCID 86643464, compound

Product 1

HCID 86643463HCID 86643463, compound

Procedure

Following the procedure of Example 128b, (R)-2,6-dichloro-9-(tetrahydrofuran-3-yl)-9H-purine (b) was reacted with tyramine. The crude reaction mixture was purified by reverse-phase preparative HPLC. MS m/z 360.1 (M+1).

Workup

  1. customThe crude reaction mixture
  2. customwas purified by reverse-phase preparative HPLC

Sources & evidence

ORD record
ord-d8218a4d94d2448f8c758e08153efec8
Source dataset
uspto-grants-2015_01
Patent number
US08927281B2

Reaction notes

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