反应详情

Following the procedure of Example 15e, 2-(benzo[b]thiophen-3-yl)-6-chloro-9-isopropyl-9H-purine (b) (80 mg, 0.243 mmol) was reacted with serotonin. The reaction mixture was concentrated, then aqueous sodium bicarbonate solution was added. The mixture was extracted with ethyl acetate. The organic fractions were combined, dried over sodium sulfate, and concentrated. The residue was purified by silica gel chromatography (0 to 5% MeOH in DCM eluant) to afford the title compound as an off-white solid. MS m/z 469.2 (M+1).

1. concentrationThe reaction mixture was concentrated
2. additionaqueous sodium bicarbonate solution was added
3. extractionThe mixture was extracted with ethyl acetate
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe residue was purified by silica gel chromatography (0 to 5% MeOH in DCM eluant)