Lithium → HCID 58289526, compound

HRID 1422537Notes

Reaction equation

HRID 1422537 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([Cl:17])[C:8]([O:12][CH2:13][CH2:14][O:15][CH3:16])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:18]2C=C[CH:21]=[C:20]([CH:24]([CH3:26])[CH3:25])[N:19]=2)[CH:3]=1.[Li].C(C1N=C(C([O-])=O)[S:34]C=1)(C)C.NC1C(Cl)=C(OC)C=CC=1C(=O)C>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([Cl:17])[C:8]([O:12][CH2:13][CH2:14][O:15][CH3:16])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:18]2[S:34][CH:21]=[C:20]([CH:24]([CH3:26])[CH3:25])[N:19]=2)[CH:3]=1

Participants

5

Reactant 4

HCID 3028194LithiumHCID 28063557HCID 28063557, compoundHCID 299199881-(2-Amino-3-chloro-4-methoxyphenyl)ethanoneHCID 58289568HCID 58289568, compound

Product 1

HCID 58289526HCID 58289526, compound

Procedure

4,8-Dichloro-2-(4-isopropyl-thiazol-2-yl)-7-(2-methoxy-ethoxy)-quinoline was prepared in a similar fashion as 4,8-Dichloro-2-(6-isopropyl-pyridin-2-yl)-7-(2-methoxy-ethoxy)-quinoline except that the lithium salt of 4-isopropyl-thiazole-2-carboxylate was used instead of 6-isopropyl-pyridine-2-carboxylic acid and 1-(2-Amino-3-chloro-4-methoxy-phenyl)-ethanone was used instead of 1-[2-amino-3-chloro-4-(2-methoxy-ethoxy)-phenyl]-ethanone

Sources & evidence

ORD record
ord-f87c0f62ae9e46b2855a81a045286bbf
Source dataset
uspto-grants-2015_01
Patent number
US08927484B2

Reaction notes

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