2-(Propan-2-yl)-1,3-thiazole-4-carboxylic acid → HCID 58289649, compound

HRID 1422538Notes

Reaction equation

HRID 1422538 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([Cl:17])[C:8]([O:12][CH2:13]COC)=[CH:9][CH:10]=2)[N:5]=[C:4]([C:18]2[CH:23]=CC=[C:20]([CH:24]([CH3:26])[CH3:25])[N:19]=2)[CH:3]=1.C(C1[S:31]C=C(C(O)=O)N=1)(C)C.NC1C(Cl)=C(OC)C=CC=1C(=O)C>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([Cl:17])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:18]2[N:19]=[C:20]([CH:24]([CH3:26])[CH3:25])[S:31][CH:23]=2)[CH:3]=1

Participants

4

Reactant 3

HCID 225730652-(Propan-2-yl)-1,3-thiazole-4-carboxylic acidHCID 299199881-(2-Amino-3-chloro-4-methoxyphenyl)ethanoneHCID 58289568HCID 58289568, compound

Product 1

HCID 58289649HCID 58289649, compound

Procedure

4,8-Dichloro-2-(2-isopropyl-thiazol-4-yl)-7-methoxy-quinoline was prepared in a similar fashion as 4,8-dichloro-2-(6-isopropyl-pyridin-2-yl)-7-(2-methoxy-ethoxy)-quinoline except that 2-isopropyl-thiazole-4-carboxylic acid was used instead of 6-isopropyl-pyridine-2-carboxylic acid and 1-(2-Amino-3-chloro-4-methoxy-phenyl)-ethanone was used instead of 1-[2-amino-3-chloro-4-(2-methoxy-ethoxy)-phenyl]-ethanone

Sources & evidence

ORD record
ord-c83be60a1a804dc697b43f5397a20aea
Source dataset
uspto-grants-2015_01
Patent number
US08927484B2

Reaction notes

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