Hydrochloric Acid → HCID 14523915, compound

Participants

Reaction Steps

3-O-(tert-butyldimethyl-silyl)-4,6-di-O-acetyl-D-glucal (11.9 g, 34.5 mmol) was dissolved in methanol (120 mL), then 1M solution of sodium methanolate in methanol (1 mL) was added. The reaction mixture was stirred in room temperature for 6 hours and 1M water solution of hydrochloric acid (1 mL) was added. Reaction mixture was evaporated to dryness and crude product was purified by column chromatography (SilicaGel 60 Merck), using hexanes:ethyl acetate as eluents to give 7.7 g of 3-O-(tert-butyldimethyl-silyl)-D-glucal, yield (85%), mp. 55.0-56.0° C.

Provenance & Evidence