HCID 78035248, compound → HCID 86675578, compound

Participants

Reaction Steps

tert-Butyl (1SR,7SR)-1-(2-fluoro-5-nitrophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (intermediate rac-A7a) (68 mg; 0.18 mmol) was dissolved in 20 ml methanol under argon and 10% palladium on carbon (Pd/C) (28 mg, 15 mol %) was added. The atmosphere of the reaction system was replaced with hydrogen, followed by stiffing at 23° C. for 3 hours. More 10% Pd/C (67 mg) was added and stiffing was continued under hydrogen atmosphere for 20 hours. The reaction mixture was filtered and evaporated to give the tert-butyl (1SR,7SR)-1-(5-amino-2-fluorophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (53 mg; 85%) as a grey foam which was used in the next step without further purification. MS (ISP): m/z=352.3 [(M+H)+].

Provenance & Evidence