5-Chloro-2-picolinic acid → HCID 71202301, compound

Participants

Reaction Steps

Prepared in an analogous manner as described for intermediate rac-A9a from tert-butyl (1S,7S)-1-(5-amino-2-fluorophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (intermediate (−)-A8a) (85 mg, 0.24 mmol) and 5-chloro-2-pyridinecarboxylic acid to give the tert-butyl (1S,7S)-1-(5-(5-chloropicolinamido)-2-fluorophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (70 mg, 50% yield) as a light yellow oil. MS (ISP): m/z=391.0 [(M-Boc+H)+] and 393.1 [(M-Boc+2+H)+].

Provenance & Evidence