5-Cyanopyridine-2-carboxylic acid → HCID 71204773, compound

Participants

Reaction Steps

Prepared in an analogous manner as described for intermediate rac-A9a from tert-butyl (1S,7S)-1-(5-amino-2-fluorophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (intermediate (−)-A8a) (86.7 mg, 247 μmol) and commercially available 5-cyanopicolinic acid to give the tert-butyl (1S,7S)-1-(5-(5-cyanopicolinamido)-2-fluorophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (65 mg, 135 μmol, 46.5% yield) as a yellow oil. MS (ISP): m/z=482.1 [(M+H)+].

Provenance & Evidence