5-Chloro-2-picolinic acid → HCID 78035252, compound

Participants

Reaction Steps

Prepared in an analogous manner as described for intermediate rac-A9a from tert-butyl (1SR,7SR)-1-(5-amino-2-chlorophenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (intermediate rac-A8b) (56 mg, 152 μmol) and 5-chloro-2-pyridinecarboxylic acid to give the tert-butyl (1SR,7SR)-1-(2-chloro-5-(5-chloropicolinamido)phenyl)-4-thia-2-azabicyclo[5.1.0]oct-2-en-3-ylcarbamate (42 mg, 82.8 μmol, 54.4% yield) as a light brown oil. MS (ISP): m/z=407.2 [(M-Boc+H)+], 409.2 [(M-Boc+2+H)+] and 411.0 [(M-Boc+4+H)+].

Provenance & Evidence