HRID1422617

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4Br)ccc21

HCID86700774

未命名化合物

HCID90313967

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCC4(CC3)CC4)ccc21

HCID90313904

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from {(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and (6-azonia-spiro[2.5]octan-6-yl)methyltrifluoroborate following a procedure analogous to that described for Intermediate 3. LC (method 1): tR=0.96 min; Mass spectrum (ESI+): m/z=516 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-077a224f05ba4fb8bb831350d5c10b39
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08927531B2
来源说明: uspto-grants-2015_01

反应 SMILES

[CH3:1][O:2][C:3](=[O:29])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19](Br)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[CH2:30]1[C:32]2([CH2:37][CH2:36][NH+:35]([CH2:38][B-](F)(F)F)[CH2:34][CH2:33]2)[CH2:31]1>>[CH3:1][O:2][C:3](=[O:29])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:38][N:35]5[CH2:36][CH2:37][C:32]6([CH2:30][CH2:31]6)[CH2:33][CH2:34]5)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1