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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422619Generated: November 4, 2026

{(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 90313717, compound

https://huagongshe.com/reaction/1422619

Reaction equation

Participants

RoleNameHCIDCharge
Reactant{(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86700774—
Reactant(1-Oxa-8-azonia-spiro[4.5]dec-8-yl)methyltrifluoroborateHCID 90313784—
ProductHCID 90313717HCID 90313717—

Reaction Steps

The title compound is prepared from {(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and (1-oxa-8-azonia-spiro[4.5]dec-8-yl)methyltrifluoroborate following a procedure analogous to that described for Intermediate 3. LC (method 1): tR=0.93 min; Mass spectrum (ESI+): m/z=546 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08927531B2
Source datasetuspto-grants-2015_01
ORD IDord-2c5a3337db904e7bbefbe57abdd1718c
Source noteuspto-grants-2015_01