HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionyl chloride → {(S)-6-[(R)-4-(4-Propionyl-piperazin-1-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | {(S)-6-[(R)-4-piperazin-1-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 90313619 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | {(S)-6-[(R)-4-(4-Propionyl-piperazin-1-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 90312787 | — |
Reaction Steps
The title compound is prepared from propionyl chloride and {(S)-6-[(R)-4-piperazin-1-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester following a procedure analogous to that described for Intermediate 27; pyridine instead of triethylamine is used. LC (method 4): tR=0.97 min; Mass spectrum (ESI+): m/z=547 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927531B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-92f59a8cf6fb4e2e9413b53ac73a1a6a |
| Source note | uspto-grants-2015_01 |