HRID1422625

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7917

Isopropyl chloroformate

C4H7ClO2

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCNCC3)ccc21

HCID90313619

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCN(C(=O)OC(C)C)CC3)ccc21

HCID90313678

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from isopropyl chloroformate and {(S)-6-[(R)-4-piperazin-1-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester following a procedure analogous to that described for Intermediate 27. LC (method 4): tR=1.05 min; Mass spectrum (ESI+): m/z=577 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-74bfe72f983b4a08ae8053aed9974730
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08927531B2
来源说明: uspto-grants-2015_01

反应 SMILES

Cl[C:2]([O:4][CH:5]([CH3:7])[CH3:6])=[O:3].[CH3:8][O:9][C:10](=[O:42])[CH2:11][C@H:12]1[C:16]2[CH:17]=[CH:18][C:19]([O:21][C@H:22]3[C:30]4[C:25](=[C:26]([CH2:35][N:36]5[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]5)[C:27]([C:31]([F:34])([F:33])[F:32])=[CH:28][CH:29]=4)[CH2:24][CH2:23]3)=[CH:20][C:15]=2[O:14][CH2:13]1>>[CH3:8][O:9][C:10](=[O:42])[CH2:11][C@H:12]1[C:16]2[CH:17]=[CH:18][C:19]([O:21][C@H:22]3[C:30]4[C:25](=[C:26]([CH2:35][N:36]5[CH2:37][CH2:38][N:39]([C:2]([O:4][CH:5]([CH3:7])[CH3:6])=[O:3])[CH2:40][CH2:41]5)[C:27]([C:31]([F:32])([F:33])[F:34])=[CH:28][CH:29]=4)[CH2:24][CH2:23]3)=[CH:20][C:15]=2[O:14][CH2:13]1