3,4-Dihydroisoquinoline → {(S)-6-[(R)-4-(3,4-Dihydro-isoquinolin-2-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

HRID 1422633노트

반응식

HRID 1422633 반응식
[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28]Br)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[CH:31]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH2:34][CH2:33][N:32]=1>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28][N:32]5[CH2:33][CH2:34][C:35]6[C:40](=[CH:39][CH:38]=[CH:37][CH:36]=6)[CH2:31]5)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

참가 물질

3

반응물 2

HCID 767053,4-DihydroisoquinolineHCID 86700813{(S)-6-[(R)-4-Bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

생성물 1

HCID 90313135{(S)-6-[(R)-4-(3,4-Dihydro-isoquinolin-2-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

실험 절차

The title compound is prepared from {(S)-6-[(R)-4-bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 3,4-dihydro-isoquinoline following a procedure analogous to that described for Intermediate 42. Mass spectrum (ESI+): m/z=538 [M+H]+.

출처 및 근거

ORD 기록
ord-c4c13924aa9f460a9cef12d93c4d3c69
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927531B2

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