5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine → HCID 90314122, compound

Participants

Reaction Steps

The methyl ester of the title compound, {(S)-6-[(R)-4-(5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester, is prepared from {(S)-6-[(R)-4-bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine following a procedure analogous to that described for Intermediate 42. The crude product is directly submitted to the saponification conditions described for Example 1 to give the title compound upon chromatography on reversed phase (HPLC; acetonitrile/water). LC (method 6): tR=0.76 min; Mass spectrum (ESI+): m/z=514 [M+H]+.

Provenance & Evidence