3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178516918, compound

HRID 1422702Notes

Reaction equation

HRID 1422702 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([F:12])=[CH:7][CH:8]=2)[N:3]=1.C(O[C:18](=[O:29])[NH:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([CH2:26][CH2:27][OH:28])[CH2:22][CH2:21]1)(C)(C)C.[O:30]=[C:31]1[NH:36][C:35]2[CH:37]=[C:38](C(O)=O)[CH:39]=[CH:40][C:34]=2[S:33][CH2:32]1>>[F:12][C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:28][CH2:27][CH2:26][C@H:23]3[CH2:22][CH2:21][C@H:20]([NH:19][C:18]([C:38]4[CH:39]=[CH:40][C:34]5[S:33][CH2:32][C:31](=[O:30])[NH:36][C:35]=5[CH:37]=4)=[O:29])[CH2:25][CH2:24]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 714639612-Chloro-7-fluoroquinoxalineHCID 178453925HCID 178453925, compound

Product 1

HCID 178516918HCID 178516918, compound

Procedure

The title compound is prepared as a white amorphous lyophilizated solid following Scheme 1 and in analogy to Example 1 using 2-chloro-7-fluoro-quinoxaline, [trans-4-(2-hydroxy-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-371aaab6ad014d5f91f1c299baf3b524
Source dataset
uspto-grants-2015_01
Patent number
US08927542B2

Reaction notes

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