HRID1422713

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID220632

3-bromo-1,1,1-trifluoropropan-2-ol

C3H4BrF3O

HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

HCID760993

3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid

C9H7NO3S

HCID12686415

2-Chloro-7-methoxyquinoxaline

C9H7ClN2O

PRODUCTS

生成物

结构：COc1ccc2ncc(OC(CN3CCC(NC(=O)c4ccc5c(c4)NC(=O)CS5)CC3)C(F)(F)F)nc2c1

HCID46852230

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as an off-white lyophilizated powder following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, 3-bromo-1,1,1-trifluoro-2-propanol, piperidin-4-yl-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6644481659194c4d84c7860baa13e123
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08927542B2
来源说明: uspto-grants-2015_01

反应 SMILES

Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:15][CH:16]([OH:21])[C:17]([F:20])([F:19])[F:18].C(O[C:27](=[O:35])[NH:28][CH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)(C)(C)C.[O:36]=[C:37]1[NH:42][C:41]2[CH:43]=[C:44](C(O)=O)[CH:45]=[CH:46][C:40]=2[S:39][CH2:38]1>>[F:18][C:17]([F:20])([F:19])[CH:16]([O:21][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1)[CH2:15][N:32]1[CH2:31][CH2:30][CH:29]([NH:28][C:27]([C:44]2[CH:45]=[CH:46][C:40]3[S:39][CH2:38][C:37](=[O:36])[NH:42][C:41]=3[CH:43]=2)=[O:35])[CH2:34][CH2:33]1