3-Bromo-1-propanol → HCID 131732228, compound

HRID 1422724Notes

Reaction equation

HRID 1422724 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:15][CH2:16][CH2:17][OH:18].C(O[C:24](=[O:31])[NH:25][CH:26]1[CH2:30][CH2:29][NH:28][CH2:27]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[CH3:13][O:12][C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:18][CH2:17][CH2:16][CH2:15][N:28]3[CH2:29][CH2:30][CH:26]([NH:25][C:24]([C:40]4[CH:41]=[CH:42][C:36]5[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)=[O:31])[CH2:27]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 123083-Bromo-1-propanolHCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 126864152-Chloro-7-methoxyquinoxaline

Product 1

HCID 131732228HCID 131732228, compound

Procedure

The title compound is prepared as a white solid following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, 3-bromo-propan-1-ol, pyrrolidin-3-yl-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-2e8f175222c249fe907557f78663d14a
Source dataset
uspto-grants-2015_01
Patent number
US08927542B2

Reaction notes

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