HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethanol → 5-Thiophen-2-yl-isoxazole-3-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-yloxy)-ethyl]-pyrrolidin-3-ylmethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | 5-(Thiophen-2-yl)-1,2-oxazole-3-carboxylic acid | HCID 3157098 | — |
| Reactant | tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate | HCID 4250767 | — |
| Reactant | 2-Chloro-7-methoxyquinoxaline | HCID 12686415 | — |
| Product | 5-Thiophen-2-yl-isoxazole-3-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-yloxy)-ethyl]-pyrrolidin-3-ylmethyl}-amide | HCID 66747397 | — |
Reaction Steps
The title compound is prepared as an orange semi-solid following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, 2-bromo-ethanol, pyrrolidin-3-ylmethyl-carbamic acid tert-butyl ester and 5-thiophen-2-yl-isoxazole-3-carboxylic acid as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927542B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f057962de8104ab58c1f00b05f7393db |
| Source note | uspto-grants-2015_01 |