HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Thiophen-2-yl-isoxazole-3-carbaldehyde → {1-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-yl}-(5-thiophen-2-yl-isoxazol-3-ylmethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Thiophen-2-yl-isoxazole-3-carbaldehyde | HCID 2776546 | — |
| Reactant | 1-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine | HCID 66746530 | — |
| Product | {1-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-yl}-(5-thiophen-2-yl-isoxazol-3-ylmethyl)-amine | HCID 46852846 | — |
Reaction Steps
The title compound is prepared as a yellow oil (57 mg, 52% yield) following Scheme 3 and in analogy to Example 40 using 5-thiophen-2-yl-isoxazole-3-carbaldehyde (43 mg, 0.22 mmol 1.0 eq) and 1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine (70 mg, 0.22 mmol, 1.0 eq) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927542B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-b8d5905b755b43b7917f848b7a038039 |
| Source note | uspto-grants-2015_01 |