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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1422800Generated: October 27, 2026

[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester → 7-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[2-(7-methoxy-3-methyl-quinoxalin-2-yloxy)-ethyl]-piperidin-4-yl}-amide

https://huagongshe.com/reaction/1422800

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl esterHCID 45076484—
Reactant3-Chloro-6-methoxy-2-methylquinoxalineHCID 46741340—
Reactant7-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acidHCID 59560634—
Product7-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[2-(7-methoxy-3-methyl-quinoxalin-2-yloxy)-ethyl]-piperidin-4-yl}-amideHCID 66747359—

Reaction Steps

The title compound is prepared as a light yellow lyophilizated powder following Scheme 1 and in analogy to Example 1 using 3-chloro-6-methoxy-2-methyl-quinoxaline, [1-(2-hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 7-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08927542B2
Source datasetuspto-grants-2015_01
ORD IDord-640a1f3b0dc84f01975308b3b9aa20cf
Source noteuspto-grants-2015_01