2-Mercaptoethanol → HCID 46853487, compound

HRID 1422824Notes

Reaction equation

HRID 1422824 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[C:5]([O:14][CH3:15])[C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.[SH:16][CH2:17][CH2:18]O.[NH:20]1[CH2:25][CH2:24][CH:23]([NH:26][C:27](=[O:29])O)[CH2:22][CH2:21]1.[O:30]=[C:31]1[NH:36][C:35]2[CH:37]=[C:38](C(O)=O)[CH:39]=[CH:40][C:34]=2[S:33][CH2:32]1>>[CH3:13][O:12][C:6]1[C:5]([O:14][CH3:15])=[C:4]2[C:9]([N:10]=[CH:11][C:2]([S:16][CH2:17][CH2:18][N:20]3[CH2:21][CH2:22][CH:23]([NH:26][C:27]([C:38]4[CH:39]=[CH:40][C:34]5[S:33][CH2:32][C:31](=[O:30])[NH:36][C:35]=5[CH:37]=4)=[O:29])[CH2:24][CH2:25]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 15672-MercaptoethanolHCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 19787930HCID 19787930, compoundHCID 86662010HCID 86662010, compound

Product 1

HCID 46853487HCID 46853487, compound

Procedure

The title compound is prepared as a light brown solid following Scheme 3 and in analogy to Example 35 using 2-chloro-7,8-dimethoxy-quinoxaline, 2-mercaptoethanol, piperidin-4-yl-carbamic acid tort-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-fbc6bcaee67d4fbd97e02b209bf73ad9
Source dataset
uspto-grants-2015_01
Patent number
US08927542B2

Reaction notes

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