Sodium Hydroxide → HCID 67380736, compound

Participants

Reaction Steps

A mixture of 3-(5-chloro-pyridin-2-ylamino)-benzoic acid methyl ester (315 mg, 1.2 mmol) and NaOH (200 mg, 5.0 mmol) in methanol:THF:water (1:1:1, 3 mL) was stirred at room temperature for 8 h. Solvents were evaporated. Crude mass was taken in water (40 mL), acidified to pH 4.0 and extracted with ethyl acetate to obtain 3-(5-chloro-pyridin-2-ylamino)-benzoic acid (238 mg).

Provenance & Evidence