Aniline → HCID 86726294, compound

Participants

Reaction Steps

A solution of (S)-2-tert-butoxycarbonylamino-hept-6-enoic acid (5.24 mmol), DIPEA (15.7 mmol) and aniline (5.76 mmol) was stirred at RT in DCM (70 ml) for 20 minutes before adding PyBOP (5.24 mmol) and anhydrous DMF (5 ml). The reaction mixture was stirred for 2 hours at RT. The solvent was removed under reduced pressure and the crude reaction mixture was diluted with AcOEt, washed with 5% Na2CO3, water and then with 5% aqueous citric acid and finally with brine. After removal of the solvent under reduced pressure and purification on silica gel (n-hexane/AcOEt: 9/1) the desired adduct was obtained.

Provenance & Evidence