Triethylamine → HCID 86726296, compound

Participants

Reaction Steps

A solution of DCM/DMF (10 ml, 10/2) of the trifluoroacetate salt obtained in Step A was reacted with (R)-6-oxo-piperidine-2-carboxylic acid (0.79 mmol) and PyBOP (0.79 mmol) in the presence of NEt3 (2.25 mmol) for 2 hours. The reaction mixture was diluted with DCM and washed with 5% Na2CO3, brine, 5% citric acid and brine. The organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure. The crude reaction mixture was purified through chromatography on silica gel using AcOEt/MeOH (9/1) as eluent to allow the desired adduct as a white solid.

Provenance & Evidence