Azobisisobutyronitrile → HCID 71534515, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (R)-6-oxo-piperidine-2-carboxylic acid ((S)-1-phenylcarbamoyl-hex-5-enyl)-amide (220 mg, 0.64 mmol), thioacetic acid (460 μl, 6.4 mmol) at 75° C. in degassed dioxane (7 ml) was added AIBN (105 mg, 0.64 mmol). The reaction mixture was stirred until complete conversion of the starting material as monitored by TLC analysis. The reaction mixture was cooled to 0° C. and quenched with an excess of cyclohexene under stirring, the latter being maintained for 20 minutes. Concentration under reduced pressure and purification through chromatography on silica gel using Hexane/DCM/IPA: 50/40/10 as eluent afforded the desired adduct.

Provenance & Evidence