4-Benzylamino-6-methoxy-[1,5]naphthyridin-3-ol → 4-Amino-6-methoxy-[1,5]naphthyridin-3-ol

Participants

Reaction Steps

A suspension of 4-benzylamino-6-methoxy-[1,5]naphthyridin-3-ol (50 mg, 0.18 mmol, 1.0 eq) and 70% palladium hydroxide (18 mg, 0.09 mmol, 0.5 eq) in methanol (3 mL) is stirred at room temperature under hydrogen flow (10 bars) for 72 hours. The catalyst is then removed by filtration and the solution is concentrated to afford 4-amino-6-methoxy-[1,5]naphthyridin-3-ol as a grey solid (20 mg, 59% yield) which is directly engaged in the next step.

Provenance & Evidence