3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid → HCID 178487814, compound

HRID 1422935Notes

Reaction equation

HRID 1422935 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH2:23])[CH2:19][CH2:18]3)[NH:7][C:6]2=1.[O:24]=[C:25]1[NH:30][C:29]2[CH:31]=[C:32]([C:35](O)=[O:36])[CH:33]=[CH:34][C:28]=2[O:27][CH2:26]1>>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH:23][C:35]([C:32]4[CH:33]=[CH:34][C:28]5[O:27][CH2:26][C:25](=[O:24])[NH:30][C:29]=5[CH:31]=4)=[O:36])[CH2:19][CH2:18]3)[NH:7][C:6]2=1

Participants

3

Reactant 2

HCID 7061213-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acidHCID 178487813HCID 178487813, compound

Product 1

HCID 178487814HCID 178487814, compound

Procedure

The titled compound is prepared as an off-white solid following Scheme 5 and in analogy to Example 27 using trans-4-(6-methoxy-3,4-dihydro-2H-1-oxa-4,5,9-triaza-phenanthren-3-yl)-cyclohexylamine and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-f1128ccbfe73479ab44a7591836e7e65
Source dataset
uspto-grants-2015_01
Patent number
US08927541B2

Reaction notes

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