反应详情

To a solution of 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester (290 mg, 1.0 mmol) in methanol (20 mL) is added a solution of 85% potassium hydroxide pellets (0.300 g, 3.92 mmol) in water (5.0 mL). The reaction mixture is warmed at reflux for 5 minutes, cooled to room temperature and concentrated in vacuo to remove excess methanol. The mixture is acidified to pH 4 with 1 N aqueous HCl and the resulting precipitate is collected by filtration, washed with water and dried to afford the title product.

1. temperatureThe reaction mixture is warmed
2. temperatureat reflux for 5 minutes
3. concentrationconcentrated in vacuo
4. customto remove excess methanol
5. filtrationthe resulting precipitate is collected by filtration
6. washwashed with water
7. customdried